Reactome | SLC25A12,13 exchange L-Glu and L-Asp

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SLC25A12,13 exchange L-Glu and L-Asp Show undefined attributes

catalystActivity	[CatalystActivity:10931834] acidic amino acid transmembrane transporter activity of SLC25A12,13 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10931836
displayName	SLC25A12,13 exchange L-Glu and L-Asp
eventOf	[Pathway:R-CEL-9856872] Malate-aspartate shuttle - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-70613] GOT2 transaminates OA and L-Glu - Caenorhabditis elegans [Reaction:R-CEL-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-372448] SLC25A12,13 exchange L-Glu and L-Asp - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-113553] L-Asp [mitochondrial matrix] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC25A12,13 exchange L-Glu and L-Asp H(+)(out) + L-aspartate(in) + L-glutamate(out) => H(+)(in) + L-aspartate(out) + L-glutamate(in) SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp aspartate [mitochondrial matrix] + glutamate [cytosol] => aspartate [cytosol] + glutamate [mitochondrial matrix]
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29448] L-Asp [cytosol] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix]
precedingEvent	[Reaction:R-CEL-70613] GOT2 transaminates OA and L-Glu - Caenorhabditis elegans [Reaction:R-CEL-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Caenorhabditis elegans [Reaction:R-CEL-5693783] NAALADases hydrolyse NAAG - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-372448
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9856872] Malate-aspartate shuttle [Pathway:R-CEL-8963693] Aspartate and asparagine metabolism
(precedingEvent)	[Reaction:R-CEL-70613] GOT2 transaminates OA and L-Glu [Reaction:R-CEL-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp
(inferredTo)	[Reaction:R-HSA-372448] SLC25A12,13 exchange L-Glu and L-Asp

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