Reactome | GADPH tetramer dehydrogenates GA3P

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GADPH tetramer dehydrogenates GA3P Show undefined attributes

catalystActivity	[CatalystActivity:10915544] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10915546
displayName	GADPH tetramer dehydrogenates GA3P
eventOf	[Pathway:R-CEL-70171] Glycolysis - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-9638125] PGM1:Mg2+ isomerises G1P to G6P - Caenorhabditis elegans [Reaction:R-CEL-71850] PGK complexes dephosphorylate 1,3BPG - Caenorhabditis elegans [Reaction:R-CEL-9856871] MDH1 reduces OA - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-70449] GADPH tetramer dehydrogenates GA3P - Homo sapiens
input	[SimpleEntity:R-ALL-29578] GA3P [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GADPH tetramer dehydrogenates GA3P D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ Glyceraldehyde 3 phosphate, NAD+, and orthophosphate react to form 1,3 bisphosphoglycerate and NADH + H+
output	[SimpleEntity:R-ALL-29800] 1,3BPG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-CEL-70454] TPI1 dimer isomerizes DHAP to GA3P - Caenorhabditis elegans [Reaction:R-CEL-70349] DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-70449
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CEL-9638125] PGM1:Mg2+ isomerises G1P to G6P [Reaction:R-CEL-9856871] MDH1 reduces OA [Reaction:R-CEL-71850] PGK complexes dephosphorylate 1,3BPG
(hasEvent)	[Pathway:R-CEL-70171] Glycolysis
(inferredTo)	[Reaction:R-HSA-70449] GADPH tetramer dehydrogenates GA3P

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