Reactome | UCH proteinases

Schema > Pathway > Entries

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10995535
displayName	UCH proteinases
eventOf	[Pathway:R-CEL-5688426] Deubiquitination - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-5665871] ADRM1 binds 26S proteasome - Caenorhabditis elegans [Reaction:R-CEL-5665854] ADRM1:26S proteaseome binds UCHL5 - Caenorhabditis elegans [Reaction:R-CEL-5690319] UCHL1, UCHL3 cleave ubiquitin adducts - Caenorhabditis elegans [Reaction:R-CEL-5690808] UCHL3, SENP8 cleave NEDD8 - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-5689603] UCH proteinases - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	UCH proteinases
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-5689603
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CEL-5688426] Deubiquitination
(inferredTo)	[Pathway:R-HSA-5689603] UCH proteinases