Reactome | SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)

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SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) Show undefined attributes

catalystActivity	[CatalystActivity:10963299] histone H3 methyltransferase activity of SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10963301
displayName	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)
eventOf	[Pathway:R-CEL-3214841] PKMTs methylate histone lysines - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [CandidateSet:R-CEL-4657030] Histone H3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) SETD3, SETD7, WHSC1L1, Core MLL complex methylate lysine-5 of histone H3
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [CandidateSet:R-CEL-5173296] MeK5-histone H3 [nucleoplasm]
precedingEvent	[Reaction:R-CEL-9676254] Formation of the MLL3 complex - Caenorhabditis elegans [Reaction:R-CEL-9676268] Formation of the MLL4 complex - Caenorhabditis elegans [Reaction:R-CEL-9676257] Formation of the SET1A complex - Caenorhabditis elegans [Reaction:R-CEL-9676264] Formation of the SET1B complex - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-5159245
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-3214841] PKMTs methylate histone lysines
(precedingEvent)	[Reaction:R-CEL-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)
(inferredTo)	[Reaction:R-HSA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)

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