Reactome | cwn-2 [extracellular region]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-CEL-3965385] WNT5A/WNT11 [extracellular region] - Caenorhabditis elegans
compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-CEL-4608830] WNT5A:FZD [plasma membrane] - Caenorhabditis elegans [Complex:R-CEL-5323537] RYK:WNTs [plasma membrane] - Caenorhabditis elegans
consumedByEvent	[Reaction:R-CEL-5099899] WNT5A binds FZD4 - Caenorhabditis elegans [Reaction:R-CEL-5140741] WNT5A binds FZD and ROR receptors - Caenorhabditis elegans [Reaction:R-CEL-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Caenorhabditis elegans [Reaction:R-CEL-5323545] Canonical WNT signaling through the atypical receptor RYK - Caenorhabditis elegans
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10960334
displayName	cwn-2 [extracellular region]
endCoordinate	380
hasModifiedResidue	[ModifiedResidue:10960273] N4-glycosyl-L-asparagine at unknown position [ModifiedResidue:10960274] O-palmitoleyl-L-serine at 244 (in Homo sapiens)
inDisease	false
inferredFrom	[DefinedSet:R-HSA-5323535] RYK-binding WNTs [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3247777] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] - Homo sapiens
maxDepth	1
name	cwn-2 N4GlycoAsn-PalmS WNT5A(36-380) P34889
referenceEntity	[ReferenceGeneProduct:uniprot:P34889] UniProt:P34889
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-3247777
startCoordinate	36

(input)	[Reaction:R-CEL-5323545] Canonical WNT signaling through the atypical receptor RYK [Reaction:R-CEL-5099899] WNT5A binds FZD4 [Reaction:R-CEL-5140741] WNT5A binds FZD and ROR receptors [Reaction:R-CEL-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation
(hasComponent)	[Complex:R-CEL-5323537] RYK:WNTs [plasma membrane] [Complex:R-CEL-5140740] WNT5A:FZDs/ROR [plasma membrane] [Complex:R-CEL-4608830] WNT5A:FZD [plasma membrane]
(inferredTo)	[DefinedSet:R-HSA-5323535] RYK-binding WNTs [extracellular region] [EntityWithAccessionedSequence:R-HSA-3247777] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region]
(hasCandidate)	[CandidateSet:R-CEL-3965385] WNT5A/WNT11 [extracellular region]