Reactome | daf-18 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

daf-18 [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10951502] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol] [CatalystActivity:10927845] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CEL-8847960] PTEN:p-Y387-FRK [cytosol] - Caenorhabditis elegans
consumedByEvent	[Reaction:R-CEL-8948775] MKRN1 polyubiquitinates PTEN - Caenorhabditis elegans [Reaction:R-CEL-8948800] TNKS and TNKS2 PARylate PTEN - Caenorhabditis elegans [Reaction:R-CEL-8850945] Casein kinase II phosphorylates PTEN - Caenorhabditis elegans [Reaction:R-CEL-8850997] TRIM27 binds PTEN - Caenorhabditis elegans [Reaction:R-CEL-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN - Caenorhabditis elegans [Reaction:R-CEL-8847968] PTEN binds FRK - Caenorhabditis elegans
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10927844
displayName	daf-18 [cytosol]
endCoordinate	403
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol] - Homo sapiens
maxDepth	1
name	daf-18 PTEN G5EE01
producedByEvent	[Reaction:R-CEL-8873946] OTUD3 deubiquitinates PTEN - Caenorhabditis elegans [Reaction:R-CEL-6807206] USP13 and OTUD3 deubiquitinate PTEN - Caenorhabditis elegans [Reaction:R-CEL-6807126] Deubiquitinated PTEN translocates to the cytosol - Caenorhabditis elegans
referenceEntity	[ReferenceGeneProduct:uniprot:G5EE01] UniProt:G5EE01
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-199420
startCoordinate	2

Referrals

(output)	[Reaction:R-CEL-8873946] OTUD3 deubiquitinates PTEN [Reaction:R-CEL-6807206] USP13 and OTUD3 deubiquitinate PTEN [Reaction:R-CEL-6807126] Deubiquitinated PTEN translocates to the cytosol
(input)	[Reaction:R-CEL-8948775] MKRN1 polyubiquitinates PTEN [Reaction:R-CEL-8948800] TNKS and TNKS2 PARylate PTEN [Reaction:R-CEL-8847968] PTEN binds FRK [Reaction:R-CEL-8850945] Casein kinase II phosphorylates PTEN [Reaction:R-CEL-8850997] TRIM27 binds PTEN [Reaction:R-CEL-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
(hasComponent)	[Complex:R-CEL-8847960] PTEN:p-Y387-FRK [cytosol] [Complex:R-CEL-8851000] PTEN:TRIM27 [cytosol] [Complex:R-CEL-199426] PTEN:Mg2+ [cytosol]
(physicalEntity)	[CatalystActivity:10951502] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol] [CatalystActivity:10927845] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol]

© 2026 Reactome

Cite Us!