Reactome | NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD

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NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD Show undefined attributes

catalystActivity	[CatalystActivity:10927337] nicotinate-nucleotide adenylyltransferase activity of NMNAT2:Mg2+ [Golgi membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:20699] Golgi membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10927339
displayName	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD
eventOf	[Pathway:R-CEL-196807] Nicotinate metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Caenorhabditis elegans
goBiologicalProcess	[GO_BiologicalProcess:262876] 'de novo' NAD+ biosynthetic process from L-tryptophan
inferredFrom	[Reaction:R-HSA-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-8869359] NAMN [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD nicotinate beta-D-ribonucleotide + ATP + H(+) => deamido-NAD(+) + diphosphate Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2]
output	[SimpleEntity:R-ALL-197256] NAAD [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-197235
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-196807] Nicotinate metabolism
(precedingEvent)	[Reaction:R-CEL-197271] NADSYN1 hexamer amidates NAAD to NAD+
(inferredTo)	[Reaction:R-HSA-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD

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