Reactome | AP-2 Complex [cytosol]

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AP-2 Complex [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CEL-8935902] Clathrin-coated vesicle [cytosol] - Caenorhabditis elegans [Complex:R-CEL-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] - Caenorhabditis elegans [Complex:R-CEL-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] - Caenorhabditis elegans [Complex:R-CEL-8871145] PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] - Caenorhabditis elegans [Complex:R-CEL-8871145] PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] - Caenorhabditis elegans [Complex:R-CEL-8871145] PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] - Caenorhabditis elegans
consumedByEvent	[Reaction:R-CEL-8866277] AP-2 directly binds some endocytic cargo - Caenorhabditis elegans [Reaction:R-CEL-9681616] AP2 binds chlorpromazine - Caenorhabditis elegans [Reaction:R-CEL-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Caenorhabditis elegans [Reaction:R-CEL-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Caenorhabditis elegans [BlackBoxEvent:R-CEL-3928654] Clathrin internalises EPH:EFN complexes - Caenorhabditis elegans
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10961910
displayName	AP-2 Complex [cytosol]
hasComponent	[DefinedSet:R-CEL-182144] Adaptor protein complex 2 (AP-2) large adaptins [cytosol] [EntityWithAccessionedSequence:R-CEL-182166] apb-1 [cytosol] [EntityWithAccessionedSequence:R-CEL-182197] aps-2 [cytosol] [EntityWithAccessionedSequence:R-CEL-182227] dpy-23 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-167712] AP-2 Complex [cytosol] - Homo sapiens
maxDepth	3
name	AP-2 Complex
schemaClass	Complex
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-167712
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-CEL-8871145] PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] [Complex:R-CEL-8935902] Clathrin-coated vesicle [cytosol] [Complex:R-CEL-8869191] AP-2:cargo [clathrin-coated endocytic vesicle membrane] [Complex:R-CEL-8868048] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-CEL-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-CEL-8866238] AP-2:cargo [plasma membrane] [Complex:R-CEL-9681612] AP2:chlorpromazine [cytosol] [Complex:R-CEL-3928567] EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] [Complex:R-CEL-5138434] clathrin:AP-2 [plasma membrane]
(input)	[Reaction:R-CEL-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-CEL-8866277] AP-2 directly binds some endocytic cargo [Reaction:R-CEL-9681616] AP2 binds chlorpromazine [BlackBoxEvent:R-CEL-3928654] Clathrin internalises EPH:EFN complexes
(inferredTo)	[Complex:R-HSA-167712] AP-2 Complex [cytosol]

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