Reactome | phospho-lin-35 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CEL-1363326] p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] - Caenorhabditis elegans [Complex:R-CEL-1363324] Ub-p-T401,S672,1035-RBL2 [nucleoplasm] - Caenorhabditis elegans
consumedByEvent	[Reaction:R-CEL-1363276] Dephosphorylation of p130 (RBL2) by PP2A - Caenorhabditis elegans [Reaction:R-CEL-1363328] Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex - Caenorhabditis elegans
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10946357
displayName	phospho-lin-35 [nucleoplasm]
endCoordinate	1139
hasModifiedResidue	[ModifiedResidue:10946353] O-phospho-L-threonine at 401 (in Homo sapiens) [ModifiedResidue:10946354] O-phospho-L-serine at 672 (in Homo sapiens) [ModifiedResidue:10946355] O-phospho-L-serine at 1035 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-1226084] p-T401,S672,S1035-RBL2 [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-lin-35 p-T401,S672,S1035-RBL2 G5EDT1
producedByEvent	[Reaction:R-CEL-1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex - Caenorhabditis elegans
referenceEntity	[ReferenceGeneProduct:uniprot:G5EDT1] UniProt:G5EDT1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-1226084
startCoordinate	1

(input)	[Reaction:R-CEL-1363276] Dephosphorylation of p130 (RBL2) by PP2A [Reaction:R-CEL-1363328] Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
(output)	[Reaction:R-CEL-1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
(hasComponent)	[Complex:R-CEL-1363324] Ub-p-T401,S672,1035-RBL2 [nucleoplasm] [Complex:R-CEL-1363326] p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-1226084] p-T401,S672,S1035-RBL2 [nucleoplasm]

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