Reactome | botA HC disulfide bonded [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-CBO-5228948] botA HC:LC dimer [plasma membrane] - Clostridium botulinum
created	[InstanceEdit:9616789] D'Eustachio, Peter, 2018-08-14
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	9616788
deleted	[Deleted:9616792] Deletion of instance: 181496
disease	[Disease:3632909] botulism
displayName	botA HC disulfide bonded [plasma membrane]
endCoordinate	1296
goCellularComponent	[GO_CellularComponent:6485] host cell plasma membrane
hasModifiedResidue	[InterChainCrosslinkedResidue:5228587] Inter-chain Crosslink via L-cystine (cross-link) at 454 and 430
inDisease	true
literatureReference	[LiteratureReference:5228581] Botulinum neurotoxin type A: cleavage of the heavy chain into two halves and their partial sequences [LiteratureReference:5228586] Partial amino acid sequence of the heavy and light chains of botulinum neurotoxin type A
maxDepth	1
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	botA HC disulfide bonded BoNT/A HC disulfide bonded BoNT Heavy chain Type A
referenceEntity	[ReferenceGeneProduct:uniprot:P0DPI0] UniProt:P0DPI0 botA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:168825] Clostridium botulinum
stId	R-CBO-9616788
startCoordinate	449
updateTrackers	[UpdateTracker:9901786] Update Tracker - [EntityWithAccessionedSequence:9616788] botA HC disulfide bonded [plasma membrane] - v75:[modifyName]

(updatedInstance)	[UpdateTracker:9901786] Update Tracker - [EntityWithAccessionedSequence:9616788] botA HC disulfide bonded [plasma membrane] - v75:[modifyName]
(replacementInstances)	[Deleted:9616792] Deletion of instance: 181496
(hasComponent)	[Complex:R-CBO-5228948] botA HC:LC dimer [plasma membrane]

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