Reactome | botA HC [synaptic vesicle membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:201753] synaptic vesicle membrane
created	[InstanceEdit:9616779] D'Eustachio, Peter, 2018-08-14
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	9616778
deleted	[Deleted:9616782] Deletion of instance: 5228946
disease	[Disease:3632909] botulism
displayName	botA HC [synaptic vesicle membrane]
endCoordinate	1296
goCellularComponent	[Compartment:5251407] host cell synaptic vesicle membrane
inDisease	true
literatureReference	[LiteratureReference:5228359] Botulinum neurotoxin: a marvel of protein design
maxDepth	1
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	botA HC BoNT/A HC BoNT Heavy chain Type A
producedByEvent	[BlackBoxEvent:R-HSA-5244428] botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P0DPI0] UniProt:P0DPI0 botA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:168825] Clostridium botulinum
stId	R-CBO-9616778
startCoordinate	449
updateTrackers	[UpdateTracker:9901856] Update Tracker - [EntityWithAccessionedSequence:9616778] botA HC [synaptic vesicle membrane] - v75:[modifyName]

(updatedInstance)	[UpdateTracker:9901856] Update Tracker - [EntityWithAccessionedSequence:9616778] botA HC [synaptic vesicle membrane] - v75:[modifyName]
(replacementInstances)	[Deleted:9616782] Deletion of instance: 5228946
(output)	[BlackBoxEvent:R-HSA-5244428] botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol

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