Reactome | Nuclear RNA decay

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Nuclear RNA decay Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10446316
displayName	Nuclear RNA decay
eventOf	[TopLevelPathway:R-BTA-8953854] Metabolism of RNA - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:18478] RNA catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-9930056] The NEXT complex and ZC3H18 bind CBCA:m7GpppN-RNA - Bos taurus [Reaction:R-BTA-9934522] NEXT:ZC3H18:CBCA:m7GpppN-RNA binds the RNA exosome - Bos taurus [BlackBoxEvent:R-BTA-9934763] The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA - Bos taurus [Reaction:R-BTA-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Bos taurus [Reaction:R-BTA-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Bos taurus [BlackBoxEvent:R-BTA-9935290] The RNA exosome in RNA exosome:NEXT:ZC3H4:WDR82:CBCA:capped RNA hydrolyzes capped RNA - Bos taurus [Reaction:R-BTA-9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome - Bos taurus
inferredFrom	[Pathway:R-HSA-9930044] Nuclear RNA decay - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Nuclear RNA decay
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-9930044
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-BTA-8953854] Metabolism of RNA
(inferredTo)	[Pathway:R-HSA-9930044] Nuclear RNA decay