Reactome | PSAP(195-273) dimer:PE binds and mobilizes ligands

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PSAP(195-273) dimer:PE binds and mobilizes ligands Show undefined attributes

catalystActivity	[CatalystActivity:10438553] sphingolipid activator protein activity of PSAP(195-273) dimer [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen [Compartment:3828048] multivesicular body, internal vesicle membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10438555
displayName	PSAP(195-273) dimer:PE binds and mobilizes ligands
eventOf	[Pathway:R-BTA-9840310] Glycosphingolipid catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - Bos taurus [Reaction:R-BTA-1605624] Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 - Bos taurus [Reaction:R-BTA-9841189] GLA hydrolyzes PSAP(195-273):Gal2Cer:PE - Bos taurus [Reaction:R-BTA-1605724] NEU1,4 hydrolyze PSAP(195-273):GM3:PE - Bos taurus [Reaction:R-BTA-1606807] ARSA removes sulfate from PSAP(195-273):Sulfatide - Bos taurus
inferredFrom	[Reaction:R-HSA-9840470] PSAP(195-273) dimer:PE binds and mobilizes ligands - Homo sapiens
input	[DefinedSet:R-ALL-9842141] PSAP(195-273) ligands [multivesicular body, internal vesicle membrane] [Complex:R-BTA-9842117] PSAP(195-273):PE [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	PSAP(195-273) dimer:PE binds and mobilizes ligands
output	[Complex:R-BTA-9840472] PSAP(195-273):Ligands:PE [lysosomal lumen]
precedingEvent	[Reaction:R-BTA-9842115] PSAP(195-273) dimer binds PE - Bos taurus [Reaction:R-BTA-9841189] GLA hydrolyzes PSAP(195-273):Gal2Cer:PE - Bos taurus [Reaction:R-BTA-1606807] ARSA removes sulfate from PSAP(195-273):Sulfatide - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9840470
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-BTA-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE [Reaction:R-BTA-1605724] NEU1,4 hydrolyze PSAP(195-273):GM3:PE [Reaction:R-BTA-1605624] Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 [Reaction:R-BTA-1606807] ARSA removes sulfate from PSAP(195-273):Sulfatide [Reaction:R-BTA-9841189] GLA hydrolyzes PSAP(195-273):Gal2Cer:PE
(inferredTo)	[Reaction:R-HSA-9840470] PSAP(195-273) dimer:PE binds and mobilizes ligands