Reactome | Factors involved in megakaryocyte development and platelet production

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Factors involved in megakaryocyte development and platelet production Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444892
displayName	Factors involved in megakaryocyte development and platelet production
eventOf	[TopLevelPathway:R-BTA-109582] Hemostasis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-983285] RAD51B binds RAD51C - Bos taurus [Reaction:R-BTA-983218] RAD51B:RAD51C binds single-stranded DNA - Bos taurus [Reaction:R-BTA-992708] Dual-specific AKAPs bind type I and II PKA regulatory subunits - Bos taurus [Reaction:R-BTA-992703] Mitofusins trans-interact linking mitochondria prior to fusion - Bos taurus [Reaction:R-BTA-994106] HP1 alpha binds Histone H3K9(me)3 - Bos taurus [Reaction:R-BTA-994137] ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 - Bos taurus [Reaction:R-BTA-994140] ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 - Bos taurus [Reaction:R-BTA-2267372] ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 - Bos taurus [Reaction:R-BTA-996727] REST recruits the BHC complex - Bos taurus [Reaction:R-BTA-996755] ZFPM proteins bind GATA proteins - Bos taurus [Reaction:R-BTA-997263] JMJD1C demethylates H3K9 mono- and di-methylation - Bos taurus [Reaction:R-BTA-997237] SH2B proteins bind JAK2 - Bos taurus [Reaction:R-BTA-1008248] Adenylate Kinase 3 is a GTP-AMP phosphotransferase - Bos taurus [Reaction:R-BTA-1008200] NFE2 binds the beta globin locus control region - Bos taurus [Reaction:R-BTA-1011576] EHD proteins interact with Rabenosyn-5 - Bos taurus [Reaction:R-BTA-1011600] Rabenosyn-5 connects Rab5 to VPS-45 - Bos taurus [Reaction:R-BTA-1011598] DOCKs bind to RhoGEFs - Bos taurus [Pathway:R-BTA-983189] Kinesins - Bos taurus
inferredFrom	[Pathway:R-HSA-983231] Factors involved in megakaryocyte development and platelet production - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Factors involved in megakaryocyte development and platelet production
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-983231
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-BTA-109582] Hemostasis
(inferredTo)	[Pathway:R-HSA-983231] Factors involved in megakaryocyte development and platelet production

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