Reactome | MIB2 ubiquitinates CYLD at K338, K530

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MIB2 ubiquitinates CYLD at K338, K530 Show undefined attributes

catalystActivity	[CatalystActivity:10437347] ubiquitin-protein transferase activity of MIB2:CYLD:UBE2D2 [cytosol]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10437349
displayName	MIB2 ubiquitinates CYLD at K338, K530
eventOf	[Pathway:R-BTA-5357905] Regulation of TNFR1 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9815507] MIB2 ubiquitinates CYLD at K338, K530 - Homo sapiens
input	[Complex:R-BTA-9816107] MIB2:CYLD:UBE2D2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MIB2 ubiquitinates CYLD at K338, K530
output	[EntityWithAccessionedSequence:R-BTA-9818664] K48polyUb-K338, K530-CYLD [cytosol] [EntityWithAccessionedSequence:R-BTA-1472879] MIB2 [cytosol] [EntityWithAccessionedSequence:R-BTA-8864160] UBE2D1 [cytosol]
precedingEvent	[Reaction:R-BTA-9815510] MIB2 binds CYLD - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-9815507
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5357905] Regulation of TNFR1 signaling
(inferredTo)	[BlackBoxEvent:R-HSA-9815507] MIB2 ubiquitinates CYLD at K338, K530

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