Reactome | Regulation of TNFR1 signaling

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Regulation of TNFR1 signaling Show undefined attributes

created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10313226
displayName	Regulation of TNFR1 signaling
eventOf	[Pathway:R-BTA-75893] TNF signaling - Bos taurus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:383947] regulation of tumor necrosis factor-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-BTA-8863101] SPPL2a/b cleaves TNF(1-76) - Bos taurus [Reaction:R-BTA-5626953] TNF-?:TNFR1 binds DENN/MADD - Bos taurus [Reaction:R-BTA-5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex - Bos taurus [BlackBoxEvent:R-BTA-5634228] TRAF1 is cleaved by caspases - Bos taurus [BlackBoxEvent:R-BTA-5357828] RIPK1 is cleaved by CASP8 - Bos taurus [Reaction:R-BTA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Bos taurus [BlackBoxEvent:R-BTA-9697747] Caspase-8 and FLIP(L) processing at TNFR signaling complex - Bos taurus [BlackBoxEvent:R-BTA-9697750] RIPK1 is cleaved by CASP8:FLIP(L) - Bos taurus [Reaction:R-BTA-5626962] GNB2L1 binds IKKA:IKKB:NEMO - Bos taurus [Reaction:R-BTA-5693055] TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes - Bos taurus [Reaction:R-BTA-5693108] TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains - Bos taurus [Reaction:R-BTA-5357928] CLIP3 and CYLD bind TNF signaling complex - Bos taurus [BlackBoxEvent:R-BTA-5357845] K63polyUb-RIPK1 is deubiquitinated - Bos taurus [BlackBoxEvent:R-BTA-9793679] LUBAC ubiquitinates RIPK1 at K627 - Bos taurus [Reaction:R-BTA-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex - Bos taurus [BlackBoxEvent:R-BTA-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex - Bos taurus [BlackBoxEvent:R-BTA-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Bos taurus [BlackBoxEvent:R-BTA-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex - Bos taurus [Reaction:R-BTA-9796368] RIPK1 binds STUB1 - Bos taurus [BlackBoxEvent:R-BTA-9796387] STUB1 ubiquitinates RIPK1 at K571, K604, K627 - Bos taurus [Reaction:R-BTA-9796342] MIB2 binds RIPK1 within TNF-?:TNFR1:TRADD:RIPK1:TRAF2 - Bos taurus [BlackBoxEvent:R-BTA-9796346] MIB2 ubiquitinates RIPK1 at K377, K604, K634 - Bos taurus [Reaction:R-BTA-9815510] MIB2 binds CYLD - Bos taurus [BlackBoxEvent:R-BTA-9815507] MIB2 ubiquitinates CYLD at K338, K530 - Bos taurus [Reaction:R-BTA-9796617] MIB2 binds CFLAR - Bos taurus [BlackBoxEvent:R-BTA-9796626] MIB2 ubiquitinates CFLAR - Bos taurus [Reaction:R-BTA-9815501] MAPKAPK2 phosphorylates RIPK1 at S320 - Bos taurus [Reaction:R-BTA-9817411] TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex - Bos taurus [Reaction:R-BTA-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189 - Bos taurus [Reaction:R-BTA-9819106] ULK1 phosphorylates RIPK1 at S357 - Bos taurus [Reaction:R-BTA-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25 - Bos taurus [Reaction:R-BTA-5357831] CHUK, IKBKB phosphorylate CYLD at S418 - Bos taurus [Reaction:R-BTA-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - Bos taurus [Reaction:R-BTA-9824874] OPTN recruits CYLD to the TNFR1 complex - Bos taurus [Reaction:R-BTA-9823816] OPTN binds CASP8 - Bos taurus
inferredFrom	[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling - Homo sapiens
isInDisease	false
isInferred	true
name	Regulation of TNFR1 signaling
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-5357905
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-75893] TNF signaling
(inferredTo)	[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling

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