Reactome | SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol

Schema > Reaction > Entries

SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10436020] nucleoside:sodium symporter activity of SLC28A2,3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10436022
displayName	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol
eventOf	[Pathway:R-BTA-9748787] Azathioprine ADME - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Bos taurus
goBiologicalProcess	[GO_BiologicalProcess:22548] xenobiotic transmembrane transport
inferredFrom	[Reaction:R-HSA-9751037] SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol - Homo sapiens
input	[ChemicalDrug:R-ALL-9751015] 6MP [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol
output	[ChemicalDrug:R-ALL-9748998] 6MP [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9751037
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9748787] Azathioprine ADME
(precedingEvent)	[Reaction:R-BTA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP
(inferredTo)	[Reaction:R-HSA-9751037] SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol

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