Reactome | C-ter TLR7 dimer binds HCQ

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10433976
displayName	C-ter TLR7 dimer binds HCQ
eventOf	[Pathway:R-BTA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9679029] C-ter TLR7 dimer binds HCQ - Homo sapiens
input	[Complex:R-BTA-1679575] C-ter TLR7 dimer [endosome membrane] [ChemicalDrug:R-ALL-9678628] HCQ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	C-ter TLR7 dimer binds HCQ
output	[Complex:R-BTA-9678617] C-ter TLR7 dimer:HCQ [endosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9679029
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade
(inferredTo)	[Reaction:R-HSA-9679029] C-ter TLR7 dimer binds HCQ

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