Reactome | Phosphorylated SPRY2 is ubiquitinated by CBL

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Phosphorylated SPRY2 is ubiquitinated by CBL Show undefined attributes

catalystActivity	[CatalystActivity:10370450] ubiquitin protein ligase activity of Y55/Y227-pSPRY2:CBL [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10370452
displayName	Phosphorylated SPRY2 is ubiquitinated by CBL
eventOf	[Pathway:R-BTA-1295596] Spry regulation of FGF signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1295621] CBL dissociates from ubiquitinated p-SPRY2 - Bos taurus
inferredFrom	[Reaction:R-HSA-934604] Phosphorylated SPRY2 is ubiquitinated by CBL - Homo sapiens
input	[DefinedSet:R-BTA-113595] Ub [cytosol] [Complex:R-BTA-934576] Y55/Y227-pSPRY2:CBL [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated SPRY2 is ubiquitinated by CBL
output	[Complex:R-BTA-934572] Ub:Y55/Y227-pSPRY2:CBL [plasma membrane]
precedingEvent	[Reaction:R-BTA-1295622] SPRY2 binds CBL - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-934604
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1295596] Spry regulation of FGF signaling
(precedingEvent)	[Reaction:R-BTA-1295621] CBL dissociates from ubiquitinated p-SPRY2
(inferredTo)	[Reaction:R-HSA-934604] Phosphorylated SPRY2 is ubiquitinated by CBL

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