Reactome | phospho-STAT3 [cytosol]

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phospho-STAT3 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-8950427] p-Y705-STAT3:p-Y693-STAT4 [cytosol] - Bos taurus [Complex:R-BTA-8987122] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] - Bos taurus [Complex:R-BTA-8952748] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] - Bos taurus [Complex:R-BTA-8952746] p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] - Bos taurus
consumedByEvent	[Reaction:R-BTA-8950780] p-Y705-STAT3 binds p-Y693-STAT4 - Bos taurus [BlackBoxEvent:R-BTA-6784765] p-Y705-STAT3 dimerizes - Bos taurus [BlackBoxEvent:R-BTA-6784765] p-Y705-STAT3 dimerizes - Bos taurus [Reaction:R-BTA-8950782] p-STAT1 binds p-STAT3 - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10374681
displayName	phospho-STAT3 [cytosol]
endCoordinate	770
hasModifiedResidue	[ModifiedResidue:10374679] O4'-phospho-L-tyrosine at 705 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-914048] p-Y705-STAT3 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-BTA-1112571] p-Y701-STAT1, p-Y705-STAT3 [cytosol] - Bos taurus [DefinedSet:R-BTA-9006876] p-Y701-STAT1, p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [cytosol] - Bos taurus [DefinedSet:R-BTA-6788625] p-Y701-STAT1,p-Y705-STAT3,p-Y641-STAT6 [cytosol] - Bos taurus [DefinedSet:R-BTA-1433413] p-STATs [cytosol] - Bos taurus
name	phospho-STAT3 p-Y705-STAT3 F1MX38
producedByEvent	[BlackBoxEvent:R-BTA-8982162] p?Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB - Bos taurus [BlackBoxEvent:R-BTA-8952823] p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor - Bos taurus [BlackBoxEvent:R-BTA-8987236] p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 - Bos taurus [Reaction:R-BTA-6784791] p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 - Bos taurus [Reaction:R-BTA-9958877] p-Y705-STAT3 dissociates from IL6 receptor - Bos taurus [Reaction:R-BTA-8848124] PTK6 phosphorylates STAT3 - Bos taurus [BlackBoxEvent:R-BTA-8950441] p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor - Bos taurus [Reaction:R-BTA-8875817] MET phosphorylates STAT3 - Bos taurus
referenceEntity	[ReferenceGeneProduct:uniprot:F1MX38] UniProt:F1MX38
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-914048
startCoordinate	1

Referrals

(output)	[BlackBoxEvent:R-BTA-8952823] p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor [BlackBoxEvent:R-BTA-8950441] p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor [BlackBoxEvent:R-BTA-8987236] p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 [BlackBoxEvent:R-BTA-8982162] p?Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB [Reaction:R-BTA-6784791] p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [Reaction:R-BTA-8875817] MET phosphorylates STAT3 [Reaction:R-BTA-9958877] p-Y705-STAT3 dissociates from IL6 receptor [Reaction:R-BTA-8848124] PTK6 phosphorylates STAT3
(hasComponent)	[Complex:R-BTA-8952748] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] [Complex:R-BTA-8950427] p-Y705-STAT3:p-Y693-STAT4 [cytosol] [Complex:R-BTA-8952746] p-Y701-STAT1:p-Y705-STAT3:IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] [Complex:R-BTA-8987122] IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] [Complex:R-BTA-8982168] IL19:IL20RA:p-JAK1:IL20RB:p-Y705-STAT3 [plasma membrane] [Complex:R-BTA-6784779] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] [Complex:R-BTA-1112555] p-Y701-STAT1: p-Y-705-STAT3 [cytosol] [Complex:R-BTA-9958930] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:p-Y705-STAT3 [plasma membrane] [Complex:R-BTA-1112526] p-Y705-STAT3 dimer [cytosol]
(input)	[Reaction:R-BTA-8950780] p-Y705-STAT3 binds p-Y693-STAT4 [Reaction:R-BTA-8950782] p-STAT1 binds p-STAT3 [BlackBoxEvent:R-BTA-6784765] p-Y705-STAT3 dimerizes
(hasMember)	[DefinedSet:R-BTA-6788625] p-Y701-STAT1,p-Y705-STAT3,p-Y641-STAT6 [cytosol] [DefinedSet:R-BTA-1433413] p-STATs [cytosol] [DefinedSet:R-BTA-9006876] p-Y701-STAT1, p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [cytosol] [DefinedSet:R-BTA-9010175] p-Y701-STAT1,p-Y705-STAT3,p-Y694-STAT5A,p-STAT5B [cytosol] [DefinedSet:R-BTA-1112571] p-Y701-STAT1, p-Y705-STAT3 [cytosol] [DefinedSet:R-BTA-6786065] p-Y705-STAT3,p-Y641-STAT6 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-914048] p-Y705-STAT3 [cytosol]

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