Reactome | SHP1 and SHP2 bind the common beta chain

Schema > Reaction > Entries

SHP1 and SHP2 bind the common beta chain Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10369404
displayName	SHP1 and SHP2 bind the common beta chain
eventOf	[Pathway:R-BTA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB - Bos taurus
inferredFrom	[Reaction:R-HSA-909738] SHP1 and SHP2 bind the common beta chain - Homo sapiens
input	[DefinedSet:R-BTA-913422] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] [DefinedSet:R-BTA-389744] PTPN6,PTPN11 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SHP1 and SHP2 bind the common beta chain
output	[Complex:R-BTA-914086] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
precedingEvent	[Reaction:R-BTA-879907] Tyrosine kinases phosphorylate the receptor - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-909738
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling
(precedingEvent)	[Reaction:R-BTA-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB
(inferredTo)	[Reaction:R-HSA-909738] SHP1 and SHP2 bind the common beta chain

Cite Us!