Reactome | Activated NTRK2 signals through FRS2 and FRS3

Schema > Pathway > Entries

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10446048
displayName	Activated NTRK2 signals through FRS2 and FRS3
eventOf	[Pathway:R-BTA-9006115] Signaling by NTRK2 (TRKB) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:182] neurotrophin TRK receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-9028730] Activated NTRK2 binds FRS2 - Bos taurus [BlackBoxEvent:R-BTA-9032073] NTRK2-phosphorylated FRS2 binds GRB2 - Bos taurus
inferredFrom	[Pathway:R-HSA-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activated NTRK2 signals through FRS2 and FRS3
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-9028731
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-9006115] Signaling by NTRK2 (TRKB)
(inferredTo)	[Pathway:R-HSA-9028731] Activated NTRK2 signals through FRS2 and FRS3

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