Reactome | TLE tetramers bind TCF/LEF at WNT promoters

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TLE tetramers bind TCF/LEF at WNT promoters Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10426486
displayName	TLE tetramers bind TCF/LEF at WNT promoters
eventOf	[Pathway:R-BTA-4641265] Repression of WNT target genes - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8944349] TLE tetramers bind TCF/LEF at WNT promoters - Homo sapiens
input	[Complex:R-BTA-8944354] 'canonical' WNT target genes:TCF/LEF [nucleoplasm] [DefinedSet:R-BTA-3299565] TLE tetramer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	TLE tetramers bind TCF/LEF at WNT promoters
output	[Complex:R-BTA-8944351] 'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm]
precedingEvent	[Reaction:R-BTA-4641229] TLE oligomerizes - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8944349
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-4641265] Repression of WNT target genes
(inferredTo)	[Reaction:R-HSA-8944349] TLE tetramers bind TCF/LEF at WNT promoters

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