Reactome | SCF (SKP2) complex [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10333255] ubiquitin protein ligase activity of SCF (SKP2) complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-BTA-8939702] RUNX2:SCF(SKP2) [nucleoplasm] - Bos taurus [Complex:R-BTA-9708443] BACH1:FBXL17:SCF (SKP2) [nucleoplasm] - Bos taurus
consumedByEvent	[Reaction:R-BTA-8939688] SCF(SKP2) complex binds RUNX2 - Bos taurus [Reaction:R-BTA-9708525] BACH1:FBXL17 binds SCF(SKP2) complex - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10333254
displayName	SCF (SKP2) complex [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-BTA-187551] CUL1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-1234142] RBX1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-187538] SKP1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-975554] SKP2 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-8939693] SCF (SKP2) complex [nucleoplasm] - Homo sapiens
maxDepth	2
name	SCF (SKP2) complex
producedByEvent	[Reaction:R-BTA-8939706] SCF(SKP2) polyubiquitinates RUNX2 - Bos taurus [Reaction:R-BTA-9708517] FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-8939693
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-BTA-9708517] FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) [Reaction:R-BTA-8939706] SCF(SKP2) polyubiquitinates RUNX2
(input)	[Reaction:R-BTA-9708525] BACH1:FBXL17 binds SCF(SKP2) complex [Reaction:R-BTA-8939688] SCF(SKP2) complex binds RUNX2
(hasComponent)	[Complex:R-BTA-9708443] BACH1:FBXL17:SCF (SKP2) [nucleoplasm] [Complex:R-BTA-8939702] RUNX2:SCF(SKP2) [nucleoplasm]
(activeUnit)	[CatalystActivity:10425354] ubiquitin protein ligase activity of RUNX2:SCF(SKP2) [nucleoplasm]
(physicalEntity)	[CatalystActivity:10333255] ubiquitin protein ligase activity of SCF (SKP2) complex [nucleoplasm]
(inferredTo)	[Complex:R-HSA-8939693] SCF (SKP2) complex [nucleoplasm]