Reactome | Inactivation of LCK by PTPN22

Schema > Reaction > Entries

Inactivation of LCK by PTPN22 Show undefined attributes

catalystActivity	[CatalystActivity:10420675] protein tyrosine phosphatase activity of PTPN22 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10420677
displayName	Inactivation of LCK by PTPN22
eventOf	[Pathway:R-BTA-202427] Phosphorylation of CD3 and TCR zeta chains - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8852200] Inactivation of LCK by PTPN22 - Homo sapiens
input	[Complex:R-BTA-202266] Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Inactivation of LCK by PTPN22 Inactivation of LCK by LYP
output	[Complex:R-BTA-202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-BTA-202291] Activation of Lck - Bos taurus [Reaction:R-BTA-8855375] PTPN22 dissociates from CSK - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8852200
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-202427] Phosphorylation of CD3 and TCR zeta chains
(inferredTo)	[Reaction:R-HSA-8852200] Inactivation of LCK by PTPN22

Cite Us!