Reactome | Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]

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Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10352394] protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] [CatalystActivity:10352380] protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-BTA-8852200] Inactivation of LCK by PTPN22 - Bos taurus [Reaction:R-BTA-202165] Phosphorylation of ITAM motifs in CD3 complexes - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10352349
displayName	Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-BTA-167542] CD4 [plasma membrane] [Complex:R-BTA-203463] MHC Class II bearing antigen peptide [plasma membrane] [EntityWithAccessionedSequence:R-BTA-202308] phospho-LCK [cytosol] [Complex:R-BTA-198901] T-cell receptor complex [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-202266] Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] - Homo sapiens
maxDepth	6
name	Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394
producedByEvent	[Reaction:R-BTA-202291] Activation of Lck - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-202266
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-BTA-8852200] Inactivation of LCK by PTPN22 [Reaction:R-BTA-202165] Phosphorylation of ITAM motifs in CD3 complexes
(physicalEntity)	[CatalystActivity:10352394] protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] [CatalystActivity:10352380] protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
(output)	[Reaction:R-BTA-202291] Activation of Lck
(inferredTo)	[Complex:R-HSA-202266] Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]

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