Reactome | NTP Binds Active Site of RNA Polymerase II

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NTP Binds Active Site of RNA Polymerase II Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10338519
displayName	NTP Binds Active Site of RNA Polymerase II
eventOf	[Pathway:R-BTA-75953] RNA Polymerase II Transcription Initiation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-75866] Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP - Bos taurus
inferredFrom	[Reaction:R-HSA-75861] NTP Binds Active Site of RNA Polymerase II - Homo sapiens
input	2 × [SimpleEntity:R-ALL-9757634] NTP [nucleoplasm] [Complex:R-BTA-109876] pol II open pre-initiation complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NTP Binds Active Site of RNA Polymerase II
output	[Complex:R-BTA-83551] Pol II initiation complex [nucleoplasm]
precedingEvent	[Reaction:R-BTA-75949] RNA Polymerase II Promoter Opening: First Transition - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-75861
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-75953] RNA Polymerase II Transcription Initiation
(precedingEvent)	[Reaction:R-BTA-75866] Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
(inferredTo)	[Reaction:R-HSA-75861] NTP Binds Active Site of RNA Polymerase II

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