Reactome | acetoacetyl-CoA + CoA <=> 2 acetyl-CoA

Schema > Reaction > Entries

acetoacetyl-CoA + CoA <=> 2 acetyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10334670] acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10337311
displayName	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
eventOf	[Pathway:R-BTA-77108] Utilization of Ketone Bodies - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-73871] ACA-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
output	2 × [SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-74177] OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-74181
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-77108] Utilization of Ketone Bodies
(inferredTo)	[Reaction:R-HSA-74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA

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