Reactome | acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]

Schema > Reaction > Entries

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] Show undefined attributes

catalystActivity	[CatalystActivity:10335471] acetate-CoA ligase activity of ACSS2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10335473
displayName	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
eventOf	[Pathway:R-BTA-71384] Ethanol oxidation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Bos taurus
inferredFrom	[Reaction:R-HSA-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29416] CH3COO- [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
output	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-BTA-71691] acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-71735
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-71384] Ethanol oxidation
(precedingEvent)	[Reaction:R-BTA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate
(inferredTo)	[Reaction:R-HSA-71735] acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]

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