Reactome | aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]

Schema > Reaction > Entries

aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] Show undefined attributes

catalystActivity	[CatalystActivity:10334501] asparagine synthase (glutamine-hydrolyzing) activity of ASNS dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10334503
displayName	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
eventOf	[Pathway:R-BTA-8963693] Aspartate and asparagine metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Bos taurus
inferredFrom	[Reaction:R-HSA-70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] ATP + H2O + L-aspartate + L-glutamine => AMP + diphosphate + H(+) + L-asparagine + L-glutamate
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29642] L-Asn [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-BTA-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-70599
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate
(hasEvent)	[Pathway:R-BTA-8963693] Aspartate and asparagine metabolism
(inferredTo)	[Reaction:R-HSA-70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]

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