Reactome | DMGDH:FAD oxidatively demethylates DMGLY to SARC

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DMGDH:FAD oxidatively demethylates DMGLY to SARC Show undefined attributes

catalystActivity	[CatalystActivity:10412168] dimethylglycine dehydrogenase activity of DMGDH:FAD [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10412170
displayName	DMGDH:FAD oxidatively demethylates DMGLY to SARC
eventOf	[Pathway:R-BTA-6798163] Choline catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-6797913] SARDH:FAD oxidatively demethylates SARC to Gly - Bos taurus
inferredFrom	[Reaction:R-HSA-6797653] DMGDH:FAD oxidatively demethylates DMGLY to SARC - Homo sapiens
input	[SimpleEntity:R-ALL-6797923] DMGLY [mitochondrial matrix] [SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-9979086] THFpolyGlu [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	DMGDH:FAD oxidatively demethylates DMGLY to SARC (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized (electron-transfer flavoprotein) + H(+) => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced (electron-transfer flavoprotein)
output	[SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix] [SimpleEntity:R-ALL-9979072] MeTHFpolyGlu [mitochondrial matrix] [SimpleEntity:R-ALL-6797917] SARC [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-6797653
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-6797913] SARDH:FAD oxidatively demethylates SARC to Gly
(hasEvent)	[Pathway:R-BTA-6798163] Choline catabolism
(inferredTo)	[Reaction:R-HSA-6797653] DMGDH:FAD oxidatively demethylates DMGLY to SARC

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