Reactome | LIAS synthesizes lipoyl-GCSH

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LIAS synthesizes lipoyl-GCSH Show undefined attributes

catalystActivity	[CatalystActivity:10411927] lipoate synthase activity of LIAS:2(4Fe-4S) [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10411929
displayName	LIAS synthesizes lipoyl-GCSH
eventOf	[Pathway:R-BTA-9857492] Protein lipoylation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9858752] LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT - Bos taurus [Reaction:R-BTA-6792572] LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST - Bos taurus
inferredFrom	[Reaction:R-HSA-6793591] LIAS synthesizes lipoyl-GCSH - Homo sapiens
input	2 × [SimpleEntity:R-ALL-2162265] AdoMet [mitochondrial matrix] 2 × [Complex:R-BTA-2395509] FDX1 (ox.) [mitochondrial matrix] [EntityWithAccessionedSequence:R-BTA-6793586] GCSH [mitochondrial matrix] 4 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [Complex:R-BTA-6793623] LIAS:2(4Fe-4S) [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	LIAS synthesizes lipoyl-GCSH LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH
output	2 × [SimpleEntity:R-ALL-6793613] 5dAde [mitochondrial matrix] 2 × [Complex:R-BTA-2395507] FDX1 (red.) [mitochondrial matrix] 4 × [SimpleEntity:R-ALL-9857621] Fe3+ [mitochondrial matrix] [EntityWithAccessionedSequence:R-BTA-6793611] GCSH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-1655881] H2S [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-379705] L-Met [mitochondrial matrix] [Complex:R-BTA-9857620] LIAS:4Fe-4S [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-6793590] LIPT2 transfers octanoyl group to GCSH - Bos taurus [Reaction:R-BTA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-6793591
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9857492] Protein lipoylation
(precedingEvent)	[Reaction:R-BTA-9858752] LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT [Reaction:R-BTA-6792572] LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST
(inferredTo)	[Reaction:R-HSA-6793591] LIAS synthesizes lipoyl-GCSH