Reactome | RIF1 and PAX1IP bind TP53BP1 at DNA DSBs

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RIF1 and PAX1IP bind TP53BP1 at DNA DSBs Show undefined attributes

category	dissociation
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10406382
displayName	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
eventOf	[Pathway:R-BTA-5693571] Nonhomologous End-Joining (NHEJ) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5686900] TP53BP1 recruits DCLRE1C to ATM - Bos taurus [Reaction:R-BTA-5693599] Association of Ku heterodimer with ends of DNA double-strand break - Bos taurus
inferredFrom	[Reaction:R-HSA-5686685] RIF1 and PAX1IP bind TP53BP1 at DNA DSBs - Homo sapiens
input	[Complex:R-BTA-5683808] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5619395] PAXIP1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-480742] RIF1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
output	[EntityWithAccessionedSequence:R-BTA-5682582] BABAM1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682579] BABAM2 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682577] BRCC3 [nucleoplasm] [Complex:R-BTA-5686692] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] [DefinedSet:R-BTA-9707299] p-5S-BRCA1:p-2T-BARD1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682575] phospho-ABRAXAS1 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5682574] UIMC1 [nucleoplasm]
precedingEvent	[Reaction:R-BTA-5683801] CHEK2 phosphorylates BRCA1 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5686685
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5693571] Nonhomologous End-Joining (NHEJ)
(precedingEvent)	[Reaction:R-BTA-5686900] TP53BP1 recruits DCLRE1C to ATM [Reaction:R-BTA-5693599] Association of Ku heterodimer with ends of DNA double-strand break
(inferredTo)	[Reaction:R-HSA-5686685] RIF1 and PAX1IP bind TP53BP1 at DNA DSBs

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