Reactome | ATM phosphorylates TP53BP1 at DNA DSBs

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ATM phosphorylates TP53BP1 at DNA DSBs Show undefined attributes

catalystActivity	[CatalystActivity:10405557] protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10405559
displayName	ATM phosphorylates TP53BP1 at DNA DSBs
eventOf	[Pathway:R-BTA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5683405] PPP5C dephosphorylates TP53BP1 - Bos taurus [Reaction:R-BTA-5683384] UIMC1 and FAM175A bind DNA DSBs - Bos taurus
inferredFrom	[Reaction:R-HSA-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-BTA-5693591] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ATM phosphorylates TP53BP1 at DNA DSBs
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-BTA-5683417] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm]
precedingEvent	[Reaction:R-BTA-5693566] TP53BP1 associates with H4K20Me2 at DNA DSBs - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5683425
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-BTA-5683405] PPP5C dephosphorylates TP53BP1 [Reaction:R-BTA-5683384] UIMC1 and FAM175A bind DNA DSBs
(inferredTo)	[Reaction:R-HSA-5683425] ATM phosphorylates TP53BP1 at DNA DSBs