Reactome | RAF/MAP kinase cascade

Schema > Pathway > Entries

RAF/MAP kinase cascade Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445620
displayName	RAF/MAP kinase cascade
eventOf	[Pathway:R-BTA-5684996] MAPK1/MAPK3 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21714] MAPK cascade
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-BTA-9648002] RAS processing - Bos taurus [Reaction:R-BTA-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Bos taurus [Reaction:R-BTA-9649735] Intrinsic nucleotide exchange on RAS - Bos taurus [Reaction:R-BTA-5672965] RAS GEFs promote RAS nucleotide exchange - Bos taurus [Reaction:R-BTA-9658253] RAS:GTP binds PI3K - Bos taurus [Reaction:R-BTA-9660557] RAS:GTP binds RAL GDS proteins - Bos taurus [Pathway:R-BTA-5673000] RAF activation - Bos taurus [Pathway:R-BTA-5674135] MAP2K and MAPK activation - Bos taurus [Reaction:R-BTA-5674385] p-T,Y MAPKs dimerize - Bos taurus [BlackBoxEvent:R-BTA-5674387] Phosphorylated MAPKs translocate into the nucleus - Bos taurus [Reaction:R-BTA-5675206] PEA15 binds MAPK monomers and dimers - Bos taurus [Pathway:R-BTA-5675221] Negative regulation of MAPK pathway - Bos taurus
inferredFrom	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	RAF/MAP kinase cascade
precedingEvent	[Reaction:R-BTA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Bos taurus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-5673001
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(inferredTo)	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
(hasEvent)	[Pathway:R-BTA-5684996] MAPK1/MAPK3 signaling
(hasEncapsulatedEvent)	[Pathway:R-BTA-201556] Signaling by ALK [Pathway:R-BTA-9607240] FLT3 Signaling [Pathway:R-BTA-8853659] RET signaling [Pathway:R-BTA-1257604] PIP3 activates AKT signaling [Pathway:R-BTA-177929] Signaling by EGFR [Pathway:R-BTA-8848021] Signaling by PTK6 [Pathway:R-BTA-1227986] Signaling by ERBB2 [Pathway:R-BTA-9648002] RAS processing [Pathway:R-BTA-5654741] Signaling by FGFR3 [Pathway:R-BTA-187037] Signaling by NTRK1 (TRKA) [Pathway:R-BTA-5654736] Signaling by FGFR1 [Pathway:R-BTA-5654743] Signaling by FGFR4 [Pathway:R-BTA-375165] NCAM signaling for neurite out-growth [Pathway:R-BTA-881907] Gastrin-CREB signalling pathway via PKC and MAPK [Pathway:R-BTA-74752] Signaling by Insulin receptor [Pathway:R-BTA-442755] Activation of NMDA receptors and postsynaptic events [Pathway:R-BTA-9034015] Signaling by NTRK3 (TRKC) [Pathway:R-BTA-9006115] Signaling by NTRK2 (TRKB) [Pathway:R-BTA-2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [Pathway:R-BTA-2454202] Fc epsilon receptor (FCERI) signaling [Pathway:R-BTA-2172127] DAP12 interactions [Pathway:R-BTA-194138] Signaling by VEGF [Pathway:R-BTA-9009391] Extra-nuclear estrogen signaling [Pathway:R-BTA-451927] Interleukin-2 family signaling [Pathway:R-BTA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Pathway:R-BTA-186797] Signaling by PDGF [Pathway:R-BTA-1433557] Signaling by SCF-KIT [Pathway:R-BTA-8878166] Transcriptional regulation by RUNX2 [Pathway:R-BTA-1236394] Signaling by ERBB4 [Pathway:R-BTA-6806834] Signaling by MET [Pathway:R-BTA-5654738] Signaling by FGFR2

Cite Us!