Reactome | Activation of SMO

Schema > Pathway > Entries

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445556
displayName	Activation of SMO
eventOf	[Pathway:R-BTA-5632684] Hedgehog 'on' state - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-BTA-5632668] SMO translocates to the cilium - Bos taurus [Reaction:R-BTA-5633040] CSNK1A1 and ADRBK1 dissociate from p-SMO dimer - Bos taurus [Reaction:R-BTA-5633051] EFCAB7:IQCE binds EVC2:EVC - Bos taurus
inferredFrom	[Pathway:R-HSA-5635838] Activation of SMO - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activation of SMO
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-5635838
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-5632684] Hedgehog 'on' state
(inferredTo)	[Pathway:R-HSA-5635838] Activation of SMO