Reactome | RIPK1 is cleaved by CASP8

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RIPK1 is cleaved by CASP8 Show undefined attributes

catalystActivity	[CatalystActivity:10341784] cysteine-type endopeptidase activity of active caspase-8 [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10399324
displayName	RIPK1 is cleaved by CASP8
eventOf	[Pathway:R-BTA-5675482] Regulation of necroptotic cell death - Bos taurus [Pathway:R-BTA-5357905] Regulation of TNFR1 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5357828] RIPK1 is cleaved by CASP8 - Homo sapiens
input	[Complex:R-BTA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RIPK1 is cleaved by CASP8
output	[EntityWithAccessionedSequence:R-BTA-5212664] RIPK1 [cytosol] [Complex:R-BTA-5357809] TRAF2:TRADD:RIPK1(325-671):FADD [cytosol]
precedingEvent	[Reaction:R-BTA-140978] TRADD:TRAF2:RIP1 binds FADD - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-5357828
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5357905] Regulation of TNFR1 signaling [Pathway:R-BTA-5675482] Regulation of necroptotic cell death
(inferredTo)	[BlackBoxEvent:R-HSA-5357828] RIPK1 is cleaved by CASP8