Reactome | IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10366983] protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-BTA-508438] IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] - Bos taurus [Complex:R-BTA-508449] IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] - Bos taurus
consumedByEvent	[Reaction:R-BTA-508292] SYK binds IL2RB - Bos taurus [Reaction:R-BTA-452122] JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10366930
displayName	IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane]
hasComponent	[Complex:R-BTA-451939] IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] [Complex:R-BTA-451911] IL2RG:JAK3 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-451920] IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] - Homo sapiens
maxDepth	5
name	IL2:IL2R trimer:p-JAK1:JAK3
producedByEvent	[Reaction:R-BTA-451942] Within the IL-2R complex JAK3 phosphorylates JAK1 - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-451920
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasComponent)	[Complex:R-BTA-508438] IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] [Complex:R-BTA-508449] IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane]
(input)	[Reaction:R-BTA-508292] SYK binds IL2RB [Reaction:R-BTA-452122] JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
(physicalEntity)	[CatalystActivity:10366983] protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane]
(output)	[Reaction:R-BTA-451942] Within the IL-2R complex JAK3 phosphorylates JAK1
(inferredTo)	[Complex:R-HSA-451920] IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane]