Reactome | G alpha (q) auto-inactivates by hydrolysing GTP to GDP

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G alpha (q) auto-inactivates by hydrolysing GTP to GDP Show undefined attributes

catalystActivity	[CatalystActivity:10362092] GTPase activity of G-protein alpha (q/11): GTP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10362120
displayName	G alpha (q) auto-inactivates by hydrolysing GTP to GDP
eventOf	[Pathway:R-BTA-416476] G alpha (q) signalling events - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-750993] Inactive G alpha (q) reassociates with G beta:gamma - Bos taurus
inferredFrom	[Reaction:R-HSA-418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP - Homo sapiens
input	[Complex:R-BTA-167438] G protein alpha:GTP complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	G alpha (q) auto-inactivates by hydrolysing GTP to GDP
output	[Complex:R-BTA-114556] G-protein alpha (q/11):GDP [plasma membrane]
precedingEvent	[Reaction:R-BTA-418576] Dissociation of the P2Y purinoceptor 1:Gq complex - Bos taurus [Reaction:R-BTA-397835] Thrombin-activated PARs:Gq (active) dissociate - Bos taurus [Reaction:R-BTA-428752] Dissociation of the TP:Gq complex - Bos taurus [Reaction:R-BTA-749452] The Ligand:GPCR:Gq complex dissociates - Bos taurus
regulatedBy	[PositiveRegulation:10362121] Positive regulation by 'RGS proteins active for G alpha (q) [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-418582
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-416476] G alpha (q) signalling events
(precedingEvent)	[Reaction:R-BTA-750993] Inactive G alpha (q) reassociates with G beta:gamma
(inferredTo)	[Reaction:R-HSA-418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP

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