Reactome | Dissociation of the P2Y purinoceptor 1:Gq complex

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Dissociation of the P2Y purinoceptor 1:Gq complex Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10362091
displayName	Dissociation of the P2Y purinoceptor 1:Gq complex
eventOf	[Pathway:R-BTA-418592] ADP signalling through P2Y purinoceptor 1 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-418662] Src activation following P2Y purinoceptor activation - Bos taurus [Reaction:R-BTA-418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP - Bos taurus [Reaction:R-BTA-400586] G alpha (q) binds to Trio family RhoGEFs - Bos taurus [Reaction:R-BTA-416516] GRK2 sequesters activated Gq - Bos taurus [Reaction:R-BTA-416358] G alpha (q) inhibits PI3K alpha - Bos taurus [BlackBoxEvent:R-BTA-428941] P2Y purinoceptor 1 activates MAP kinase p38 alpha - Bos taurus [Reaction:R-BTA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Bos taurus [Reaction:R-BTA-392295] Gbeta:gamma recruits PI3K gamma - Bos taurus [Reaction:R-BTA-398040] Gbeta:gamma activation of PLC beta - Bos taurus [Reaction:R-BTA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Bos taurus
inferredFrom	[Reaction:R-HSA-418576] Dissociation of the P2Y purinoceptor 1:Gq complex - Homo sapiens
input	[Complex:R-BTA-418575] ADP:P2RY1:G-protein Gq (active) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Dissociation of the P2Y purinoceptor 1:Gq complex
output	[SimpleEntity:R-ALL-114564] ADP [extracellular region] [Complex:R-BTA-167438] G protein alpha:GTP complex [plasma membrane] [Complex:R-BTA-167434] G-protein beta-gamma complex [plasma membrane] [EntityWithAccessionedSequence:R-BTA-391956] P2RY1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-418576
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-418592] ADP signalling through P2Y purinoceptor 1
(precedingEvent)	[BlackBoxEvent:R-BTA-418662] Src activation following P2Y purinoceptor activation [Reaction:R-BTA-418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP [Reaction:R-BTA-400586] G alpha (q) binds to Trio family RhoGEFs [Reaction:R-BTA-416516] GRK2 sequesters activated Gq [Reaction:R-BTA-416358] G alpha (q) inhibits PI3K alpha [Reaction:R-BTA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Reaction:R-BTA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Reaction:R-BTA-392295] Gbeta:gamma recruits PI3K gamma [Reaction:R-BTA-398040] Gbeta:gamma activation of PLC beta [BlackBoxEvent:R-BTA-428941] P2Y purinoceptor 1 activates MAP kinase p38 alpha
(inferredTo)	[Reaction:R-HSA-418576] Dissociation of the P2Y purinoceptor 1:Gq complex

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