Reactome | Co-inhibition by PD-1

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Co-inhibition by PD-1 Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444428
displayName	Co-inhibition by PD-1
eventOf	[Pathway:R-BTA-388841] Regulation of T cell activation by CD28 family - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-388828] PD-1 binds B7DC and B7H1 - Bos taurus [Reaction:R-BTA-9679421] PDCD1 binds PDCD1 inhibitors - Bos taurus [Reaction:R-BTA-389762] Phosphorylation of PD-1 - Bos taurus [Reaction:R-BTA-389759] Interaction of SHP-1 or SHP-2 with phospho PD-1 - Bos taurus [Reaction:R-BTA-389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases - Bos taurus [Pathway:R-BTA-9909648] Regulation of PD-L1(CD274) expression - Bos taurus
inferredFrom	[Pathway:R-HSA-389948] Co-inhibition by PD-1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	5
name	Co-inhibition by PD-1 PD-1 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-389948
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-388841] Regulation of T cell activation by CD28 family
(hasEncapsulatedEvent)	[Pathway:R-BTA-9909615] Regulation of PD-L1(CD274) Post-translational modification
(inferredTo)	[Pathway:R-HSA-389948] Co-inhibition by PD-1

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