Reactome | Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

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Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10355149
displayName	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
eventOf	[Pathway:R-BTA-8963896] HDL assembly - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-266089] Discoidal HDL binds membrane-associated free cholesterol - Bos taurus [Reaction:R-BTA-264678] LCAT + discoidal HDL <=> LCAT:discoidal HDL complex - Bos taurus
inferredFrom	[Reaction:R-HSA-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-BTA-174720] APOA1 [extracellular region] 10 × [SimpleEntity:R-ALL-171095] CHOL [plasma membrane] 25 × [SimpleEntity:R-ALL-171142] PL [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
output	[Complex:R-BTA-216752] discoidal HDL [extracellular region]
precedingEvent	[Reaction:R-BTA-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane - Bos taurus [Reaction:R-BTA-216757] 4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-216756
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-266089] Discoidal HDL binds membrane-associated free cholesterol [Reaction:R-BTA-264678] LCAT + discoidal HDL <=> LCAT:discoidal HDL complex
(hasEvent)	[Pathway:R-BTA-8963896] HDL assembly
(inferredTo)	[Reaction:R-HSA-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

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