Reactome | Glucocorticoid biosynthesis

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Glucocorticoid biosynthesis Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444004
displayName	Glucocorticoid biosynthesis
eventOf	[Pathway:R-BTA-196071] Metabolism of steroid hormones - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21397] glucocorticoid biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-193068] CYP17A1 17-hydroxylates PREG - Bos taurus [Reaction:R-BTA-196372] 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol - Bos taurus [Reaction:R-BTA-193961] Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone - Bos taurus [Reaction:R-BTA-193981] CYP21A2 oxidises 17HPROG - Bos taurus [Reaction:R-BTA-193997] CYP11B1 oxidises 11DCORT - Bos taurus [Reaction:R-BTA-194023] HSD11B2,HSD11B1 dimer oxidise CORT to COR - Bos taurus [Reaction:R-BTA-1449687] Corticosteroids bind to CBG in blood - Bos taurus
inferredFrom	[Pathway:R-HSA-194002] Glucocorticoid biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Glucocorticoid biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-194002
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-196071] Metabolism of steroid hormones
(inferredTo)	[Pathway:R-HSA-194002] Glucocorticoid biosynthesis

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