Reactome | CYP11B1 oxidises 11DCORT

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CYP11B1 oxidises 11DCORT Show undefined attributes

catalystActivity	[CatalystActivity:10349641] steroid 11-beta-monooxygenase activity of Cytochrome P450 (CYP11B1 based) [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10349643
displayName	CYP11B1 oxidises 11DCORT
eventOf	[Pathway:R-BTA-211976] Endogenous sterols - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-193997] CYP11B1 oxidises 11DCORT - Homo sapiens
input	[SimpleEntity:R-ALL-193998] 11DCORT [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP11B1 oxidises 11DCORT 11-deoxycortisol + 2 H(+) + O2 + 2 reduced (adrenodoxin) => cortisol + H2O + 2 oxidized (adrenodoxin) 11-deoxycortisol is oxidised to cortisol by CYP11B1 11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O
output	[SimpleEntity:R-ALL-194011] CORT [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
regulatedBy	[PositiveRegulation:10349275] Positive regulation by 'POMC(138-176) [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-193997
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-211976] Endogenous sterols [Pathway:R-BTA-194002] Glucocorticoid biosynthesis
(inferredTo)	[Reaction:R-HSA-193997] CYP11B1 oxidises 11DCORT

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