Reactome | Cytosolic sensors of pathogen-associated DNA

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Cytosolic sensors of pathogen-associated DNA Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10443698
displayName	Cytosolic sensors of pathogen-associated DNA
eventOf	[Pathway:R-BTA-168249] Innate Immune System - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259970] positive regulation of type I interferon production
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-BTA-1606322] ZBP1(DAI) mediated induction of type I IFNs - Bos taurus [Pathway:R-BTA-1834941] STING mediated induction of host immune responses - Bos taurus [Pathway:R-BTA-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Bos taurus [Pathway:R-BTA-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Bos taurus [Reaction:R-BTA-3204303] MRE11 binds cytosolic DNA - Bos taurus [Pathway:R-BTA-3134975] Regulation of innate immune responses to cytosolic DNA - Bos taurus
inferredFrom	[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Cytosolic sensors of pathogen-associated DNA
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-1834949
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-168249] Innate Immune System
(hasEncapsulatedEvent)	[Pathway:R-BTA-9833482] PKR-mediated signaling
(inferredTo)	[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA

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