Reactome | EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-BTA-179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] - Bos taurus [Complex:R-BTA-180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] - Bos taurus
consumedByEvent	[Reaction:R-BTA-177944] Activation of SHP2 through the binding to phospho-Gab1 - Bos taurus [Reaction:R-BTA-177927] PI3K binds to EGF:EGFR:GRB2:GAB1 - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10347515
displayName	EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
hasComponent	[Complex:R-BTA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [DefinedSet:R-BTA-9038398] GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] - Homo sapiens
maxDepth	5
name	EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1
producedByEvent	[Reaction:R-BTA-177930] GAB1 phosphorylation by EGFR kinase - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-180286
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-BTA-177944] Activation of SHP2 through the binding to phospho-Gab1 [Reaction:R-BTA-177927] PI3K binds to EGF:EGFR:GRB2:GAB1
(hasComponent)	[Complex:R-BTA-180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] [Complex:R-BTA-179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane]
(output)	[Reaction:R-BTA-177930] GAB1 phosphorylation by EGFR kinase
(inferredTo)	[Complex:R-HSA-180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]

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