Reactome | PI3K binds to EGF:EGFR:GRB2:GAB1

Schema > Reaction > Entries

PI3K binds to EGF:EGFR:GRB2:GAB1 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10347551
displayName	PI3K binds to EGF:EGFR:GRB2:GAB1
eventOf	[Pathway:R-BTA-180292] GAB1 signalosome - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Bos taurus [Reaction:R-BTA-2316434] PI3K phosphorylates PIP2 to PIP3 - Bos taurus
inferredFrom	[Reaction:R-HSA-177927] PI3K binds to EGF:EGFR:GRB2:GAB1 - Homo sapiens
input	[Complex:R-BTA-180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] [Complex:R-BTA-1806218] PIK3CA:PIK3R1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PI3K binds to EGF:EGFR:GRB2:GAB1
output	[Complex:R-BTA-179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane]
precedingEvent	[Reaction:R-BTA-177930] GAB1 phosphorylation by EGFR kinase - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-177927
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-180292] GAB1 signalosome
(precedingEvent)	[Reaction:R-BTA-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
(inferredTo)	[Reaction:R-HSA-177927] PI3K binds to EGF:EGFR:GRB2:GAB1