Reactome | phospho-PPP1R1B [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10347684] cAMP-dependent protein kinase inhibitor activity of p-T75-DARPP32s [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-180050] p-T75-DARPP32s:PRKACA [cytosol] - Bos taurus
consumedByEvent	[Reaction:R-BTA-201790] DARPP-32 is dephosphorylated on Thr75 by PP2A - Bos taurus [Reaction:R-BTA-180073] DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10347320
displayName	phospho-PPP1R1B [cytosol]
endCoordinate	204
hasModifiedResidue	[ModifiedResidue:10347318] O-phospho-L-threonine at 75 (in Homo sapiens)
inDisease	false
inferredFrom	[DefinedSet:R-HSA-180026] p-T75-DARPP32s [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-180053] p-T75-PPP1R1B [cytosol] - Homo sapiens
maxDepth	1
name	phospho-PPP1R1B p-T75-PPP1R1B P07516
negativelyRegulates	[NegativeRegulation:10347358] Negative regulation by 'p-T75-DARPP32s [cytosol]'
producedByEvent	[Reaction:R-BTA-180047] CDK5 phosphorylates DARPP-32 on Thr75 - Bos taurus
referenceEntity	[ReferenceGeneProduct:uniprot:P07516] UniProt:P07516
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-180053
startCoordinate	1

(input)	[Reaction:R-BTA-201790] DARPP-32 is dephosphorylated on Thr75 by PP2A [Reaction:R-BTA-180073] DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function
(physicalEntity)	[CatalystActivity:10347684] cAMP-dependent protein kinase inhibitor activity of p-T75-DARPP32s [cytosol]
(output)	[Reaction:R-BTA-180047] CDK5 phosphorylates DARPP-32 on Thr75
(hasComponent)	[Complex:R-BTA-180050] p-T75-DARPP32s:PRKACA [cytosol]
(regulator)	[NegativeRegulation:10347358] Negative regulation by 'p-T75-DARPP32s [cytosol]'
(inferredTo)	[DefinedSet:R-HSA-180026] p-T75-DARPP32s [cytosol] [EntityWithAccessionedSequence:R-HSA-180053] p-T75-PPP1R1B [cytosol]

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