Reactome | MAP3K14 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10400540] protein serine/threonine kinase activity of Active NIK [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-5668450] K48polyUb-TRAF3:NIK [cytosol] - Bos taurus [Complex:R-BTA-5668511] TRAF3:NIK [cytosol] - Bos taurus
consumedByEvent	[Reaction:R-BTA-5668545] NIK autophosphorylates on T559 - Bos taurus [Reaction:R-BTA-5607721] Activation of NIK - Bos taurus [Reaction:R-BTA-392530] p-S400-Cot phosphorylates NIK - Bos taurus [Reaction:R-BTA-5607722] Active NIK phosphorylates IKKA dimer - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10361194
displayName	MAP3K14 [cytosol]
endCoordinate	947
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-168189] MAP3K14 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5607646] Active NIK [cytosol] - Homo sapiens
maxDepth	1
name	MAP3K14 E1BL08
producedByEvent	[Reaction:R-BTA-5607721] Activation of NIK - Bos taurus [BlackBoxEvent:R-BTA-5668481] Protesomal degradation of K48polyUb-TRAF3 - Bos taurus
referenceEntity	[ReferenceGeneProduct:uniprot:E1BL08] UniProt:E1BL08
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-168189
startCoordinate	1

(input)	[Reaction:R-BTA-5668545] NIK autophosphorylates on T559 [Reaction:R-BTA-5607722] Active NIK phosphorylates IKKA dimer [Reaction:R-BTA-5607721] Activation of NIK [Reaction:R-BTA-392530] p-S400-Cot phosphorylates NIK
(physicalEntity)	[CatalystActivity:10400540] protein serine/threonine kinase activity of Active NIK [cytosol]
(output)	[Reaction:R-BTA-5607721] Activation of NIK [BlackBoxEvent:R-BTA-5668481] Protesomal degradation of K48polyUb-TRAF3
(hasComponent)	[Complex:R-BTA-5668450] K48polyUb-TRAF3:NIK [cytosol] [Complex:R-BTA-5668511] TRAF3:NIK [cytosol] [Complex:R-BTA-5607681] Active NIK:p-S176,180-IKKA dimer [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-168189] MAP3K14 [cytosol] [EntityWithAccessionedSequence:R-HSA-5607646] Active NIK [cytosol]