Reactome | phospho-p-S257,T261-MAP2K4 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10345355] JUN kinase kinase activity of p-MAP2K4/p-MAP2K7 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10345354
displayName	phospho-p-S257,T261-MAP2K4 [cytosol]
endCoordinate	399
hasModifiedResidue	[ModifiedResidue:10345351] O-phospho-L-serine at 257 (in Homo sapiens) [ModifiedResidue:10345352] O-phospho-L-threonine at 261 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-168170] p-S257,T261-MAP2K4 [cytosol] - Homo sapiens [DefinedSet:R-HSA-450299] p-MAP2K4/p-MAP2K7 [cytosol] - Homo sapiens
maxDepth	1
name	phospho-p-S257,T261-MAP2K4 A0A3Q1N7I1
producedByEvent	[Reaction:R-BTA-2730896] Phosphorylation of MEK4 by MEKK1 - Bos taurus [Reaction:R-BTA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Bos taurus
referenceEntity	[ReferenceGeneProduct:uniprot:A0A3Q1N7I1] UniProt:A0A3Q1N7I1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-168170
startCoordinate	1

(output)	[Reaction:R-BTA-2730896] Phosphorylation of MEK4 by MEKK1 [Reaction:R-BTA-450337] Activated TAK1 phosphorylates MKK4/MKK7
(physicalEntity)	[CatalystActivity:10345355] JUN kinase kinase activity of p-MAP2K4/p-MAP2K7 [cytosol]
(inferredTo)	[DefinedSet:R-HSA-450299] p-MAP2K4/p-MAP2K7 [cytosol] [EntityWithAccessionedSequence:R-HSA-168170] p-S257,T261-MAP2K4 [cytosol]

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